SYSTEMS AND METHODS FOR CHARACTERIZING TOPOLOGICAL NETWORK PERTURBATIONS

摘要

Systems, computerized methods and products are disclosed herein for determining metrics for nodes in a network model of a biological system. Such systems and computerized methods can be used to quantify the response of a biological system to one or more perturbations based on measured activity data of a subset of entities in the biological system. Based on the activity data and a network model of the biological system, centrality values representative of the relative importance of a node in the network are derived. The centrality values are used for characterizing topological perturbations in the network, such as for performing sensitivity analysis, visualizing topological effects of a perturbation in the biological system, or deriving a score quantifying the response of the biological system to a perturbation such as exposure to a chemical agent.