MICRO RNAS TO TREAT STROKE, ISCHEMIC BRAIN INJURY, TRAUMATIC BRAIN INJURY, AND NEURODEGENERATIVE DISEASE

摘要

Compositions and methods for treating stroke, ischemic brain injury from cardiac arrest and resuscitation, traumatic brain injury, and neurodegenerative disease are disclosed. In particular, the invention relates to the use of miR-181, miR-29, and microRNA mimics and inhibitors thereof to modulate levels of Hsp-70 family chaperones and Bcl-2 family anti-apoptotic and pro-apoptotic proteins for treatment of neurological disorders.