SYSTEMS AND METHODS FOR MECHANICALLY STRAINED CELL CULTURE

摘要

A method for in vitro drug screening can include: providing one or more cells in vitro; introducing a chemical to the one or more cells; introducing a mechanical strain to the one or more cells in the presence of the chemical; and determining whether or not the chemical has bioactivity with respect to the one or more cells under the mechanical strain. The mechanical strain can be implemented with a well plate defining a plurality of cell culture wells and having one or more flexible substrates associated with the well plate so that each cell culture well has a fluid tight flexible cell culture substrate. A dynamic in vitro screening device can include: a top plate defining one or more cell culture wells; one or more flexible cell culture substrates operably coupled with the top plate to form fluid tight cell culture well bottoms; an a pin plate under the top plate with the one or more flexible cell culture substrates therebetween, the pin plate having one or more pin members associated with the one or more cell culture wells.