摘要 |
The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea. |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD.;ABUDUSAIMI, MAMUTI;YE, FANGGUO;SUN, JIANGQIN;MIYAMOTO, HISASHI;CHENG, JAY-FEI;OKA, DAISUKE |
发明人 |
ABUDUSAIMI, MAMUTI;YE, FANGGUO;SUN, JIANGQIN;MIYAMOTO, HISASHI;CHENG, JAY-FEI;OKA, DAISUKE |