发明名称 |
PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA |
摘要 |
Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3kDa but less than 11kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3kDa but less than 11kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases. |
申请公布号 |
WO2013033563(A1) |
申请公布日期 |
2013.03.07 |
申请号 |
WO2012US53391 |
申请日期 |
2012.08.31 |
申请人 |
NOVARTIS AG;GEALL, ANDREW;VERMA, AYUSH |
发明人 |
GEALL, ANDREW;VERMA, AYUSH |
分类号 |
A61K39/39;A61K9/00;A61K9/127 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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