发明名称 PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA
摘要 Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3kDa but less than 11kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3kDa but less than 11kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
申请公布号 WO2013033563(A1) 申请公布日期 2013.03.07
申请号 WO2012US53391 申请日期 2012.08.31
申请人 NOVARTIS AG;GEALL, ANDREW;VERMA, AYUSH 发明人 GEALL, ANDREW;VERMA, AYUSH
分类号 A61K39/39;A61K9/00;A61K9/127 主分类号 A61K39/39
代理机构 代理人
主权项
地址