发明名称 STABLE CRYSTALLINE 5-METHYLTETRAHYDROFOLATE SALT
摘要 <P>PROBLEM TO BE SOLVED: To provide a crystalline N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-5-methyl-(6S)-,-(6R)-and-(6R,S)-pteridinyl)methyl]amino]benzoyl]-L-glutamate salt (hereinafter, referred to as 5-methyltetrahydrofolate salt), and to provide its use and its manufacture method. <P>SOLUTION: The present invention relates to: a stable crystalline salt of 5-methyl-(6R,S)-,-(6S)- and-(6R)-tetrahydrofolic acid; a method for manufacturing the salt; and a method for using the salt as a component to manufacture a medicine, and as a nutrient adjuvant substance and a preparation containing the salt. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013047278(A) 申请公布日期 2013.03.07
申请号 JP20120264084 申请日期 2012.12.03
申请人 MERCK EPROVA AG 发明人 MUELLER HANS R;MOSER RUDOLF;EGGER THOMAS
分类号 C07D471/04;C07D475/04;A23L33/15;A61K31/519;A61K31/522;A61P3/02;A61P7/00;A61P7/06;A61P17/06;A61P19/02;A61P25/24;A61P29/00;A61P35/00;A61P39/02;A61P43/00 主分类号 C07D471/04
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