发明名称 |
TANDEM FC BISPECIFIC ANTIBODIES |
摘要 |
Provided herein are tandem Fcs and tandem Fc antibodies ("TFcAs"), e.g., tandem Fc bispecific antibodies ("TFcBAs"), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific. |
申请公布号 |
CA2843158(A1) |
申请公布日期 |
2013.03.07 |
申请号 |
CA20122843158 |
申请日期 |
2012.08.27 |
申请人 |
MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
HARMS, BRIAN;KOHLI, NEERAJ;LUGOVSKOY, ALEXEY;SU, STEPHEN;GEDDIE, MELISSA |
分类号 |
C07K16/28;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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