ADENO-PARVOVIRUS CHIMERA WITH ENHANCED ONCOLYTICAL POTENTIAL

摘要

Described is a chimerical adenovirus-parvovirus vector characterized in that it comprises the entire parvovirus genome inserted into a adenovirus genome, wherein: (a) the adenovirus genome is characterized by deletion of El and E3, and (b) the biological activity of the parvoviral protein NS, preferably NS1, is reduced or eliminated.