发明名称 |
SUSTAINED-RELEASE LIPID PRE-CONCENTRATE OF PHARMACOLOGICALLY ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups; b) a phospholipid; and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also, a pharmaceutical composition further comprising a pharmacologically active ingredient plus the pre-concentrate is provided. |
申请公布号 |
CA2845784(A1) |
申请公布日期 |
2013.03.07 |
申请号 |
CA20122845784 |
申请日期 |
2012.08.28 |
申请人 |
CHONG KUN DANG PHARMACEUTICAL CORP. |
发明人 |
KO, JIN YOUNG;KIM, JI YEON;PARK, SO HYUN;AN, SUNG WON;KI, MIN HYO |
分类号 |
A61K9/22;A61K9/20;A61K9/48;A61K47/30 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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