发明名称 |
Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof |
摘要 |
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an amphetamine prodrug that provides enzymatically-controlled release of amphetamine or an amphetamine analog. The composition can further comprise an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of amphetamine or the amphetamine analog from the amphetamine prodrug so as to attenuate enzymatic cleavage of the amphetamine prodrug. |
申请公布号 |
US2013059914(A1) |
申请公布日期 |
2013.03.07 |
申请号 |
US201113634524 |
申请日期 |
2011.04.08 |
申请人 |
JENKINS THOMAS E.;HUSFELD CRAIG O.;SEROOGY JULIE D.;WRAY JONATHAN W.;SIGNATURE THERAPEUTICS, INC. |
发明人 |
JENKINS THOMAS E.;HUSFELD CRAIG O.;SEROOGY JULIE D.;WRAY JONATHAN W. |
分类号 |
A61K31/197;A61K31/165;C07C237/22;C07C279/14;C12Q1/02 |
主分类号 |
A61K31/197 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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