发明名称 NOVEL MUC1 ANTIBODY
摘要 <p>An objective of the present invention is to provide a MUC1 antibody having high specificity to cancer cells. The objective has been achieved by the present inventors who found that a cancer-specific sugar chain can be specifically recognized in MUC1 and a cancer cell expressing MUC1 having such a cancer cell specific sugar chain can be recognized. The present invention provides an antibody, an antigen-binding fragment thereof or a MUC1-binding molecule, having, for example, 40-fold specificity or more for a cancer-associated structure of MUC1 as compared to that of a normal tissue-associated structure of MUC1.</p>
申请公布号 EP2565268(A1) 申请公布日期 2013.03.06
申请号 EP20110774654 申请日期 2011.04.28
申请人 SHIONOGI & CO., LTD.;NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY 发明人 NISHIMURA, SHIN-ICHIRO;NAITO, SHOICHI;OHYABU, NAOKI;TAKAHASHI, TATSUYA;NUMATA, YOSHITO;KAWAMOTO, KEIKO
分类号 C12N15/09;A61K39/395;A61P35/00;C07K16/18;C12P21/08;G01N33/53;G01N33/574 主分类号 C12N15/09
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