发明名称 |
MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION |
摘要 |
The present invention relates to binding proteins specific for Vascular Endothelial Growth Factor A (VEGF-A), in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx (wherein xxx denotes the amino acid length of the VEGF-A mature protein) binding to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration. |
申请公布号 |
EP2563400(A1) |
申请公布日期 |
2013.03.06 |
申请号 |
EP20110716429 |
申请日期 |
2011.04.29 |
申请人 |
MOLECULAR PARTNERS AG |
发明人 |
BINZ, HANS KASPAR;FORRER, PATRIK;STUMPP, MICHAEL TOBIAS |
分类号 |
A61K47/48;A61P27/02;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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