发明名称 |
ANTI-ICAM-1 SINGLE DOMAIN ANTIBODY AND USES THEREOF |
摘要 |
<p>Anti-ICAM-1 VHH single-domain antibodies (sdAbs) are generated by immunizing a llama with recombinant ICAM-1. These antibodies are linked to an imaging moiety for in vivo or ex vivo imaging of ICAM-1-related pathological conditions including atherosclerotic plaques. The antibodies may also be linked to a therapeutic agent to specifically target and treat ICAM-1-related pathological conditions.</p> |
申请公布号 |
EP2563816(A1) |
申请公布日期 |
2013.03.06 |
申请号 |
EP20110774229 |
申请日期 |
2011.04.27 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
ABULROB, ABEDELNASSER;ARBABI-GHAHROUDI, MEHDI;STANIMIROVIC, DANICA |
分类号 |
C07K16/28;A61K47/48;A61K49/16;A61K51/10 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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