发明名称 |
Process for erlotinib hydrochloride |
摘要 |
The present invention provides an improved and commercially viable process for preparation of erlotinib substantially free of N-methoxyethyl impurity, namely N-[(3-ethynylphenyl)-(2-methoxyethyl)]-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, and its pharmaceutically acceptable acid addition salts thereof in high purity and in high yield. According to the present invention, erlotinib or a pharmaceutically acceptable acid addition salt of erlotinib substantially free of N-methoxyethyl impurity is prepared by isolating erlotinib or a pharmaceutically acceptable salt of erlotinib from a solvent medium comprising dimethyl sulfoxide and an alcoholic solvent. |
申请公布号 |
US8389531(B2) |
申请公布日期 |
2013.03.05 |
申请号 |
US20070994613 |
申请日期 |
2007.07.11 |
申请人 |
PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SRINIVASA RAO THUNGATHURTHY;HETERO DRUGS LIMITED |
发明人 |
PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SRINIVASA RAO THUNGATHURTHY |
分类号 |
A01N43/54;A61K31/517;C07D239/72 |
主分类号 |
A01N43/54 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|