发明名称 |
Transgenic pig as a model of Alzheimer's disease |
摘要 |
The present invention relates to a modified pig as a model for studying Alzheimer's disease. The modified pig model displays one or more phenotypes associated with Alzheimer's disease. Disclosed is also a modified pig comprising a modified human and/or porcine APP gene, and/or PS1 gene, and/or a transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of Alzheimer's disease; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from Alzheimer's disease are disclosed. |
申请公布号 |
US8389794(B2) |
申请公布日期 |
2013.03.05 |
申请号 |
US20080529963 |
申请日期 |
2008.03.06 |
申请人 |
JOERGENSEN ARNE LUND;HOLM IDA ELISABETH;NIELSEN ANDERS LADE;JOHANSEN MARIANNE GREGERS;JAKOBSEN JANNIK EJNAR;AARHUS UNIVERSITET |
发明人 |
JOERGENSEN ARNE LUND;HOLM IDA ELISABETH;NIELSEN ANDERS LADE;JOHANSEN MARIANNE GREGERS;JAKOBSEN JANNIK EJNAR |
分类号 |
G01N33/00;A01K67/027;C12N15/00 |
主分类号 |
G01N33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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