发明名称 |
Complexes between an amphiphilic polymer and an osteogenic protein belonging to the family of BMPs |
摘要 |
The invention relates to an amphiphilic-BMP polymer complex which is physically and chemically stable and soluble in water, characterized in that: the amphiphilic polymers comprise a hydrophilic polysaccharide skeleton functionalized with hydrophobic substituents and hydrophilic groups the BMP is selected from the group of therapeutically active BMPs (Bone morphogenetic Proteins), the polymer/BMP mass ratio is lower than or equal to 700. The invention also relates to the process for preparing the amphiphilic-BMP polymer complex in an aqueous medium and in the absence of organic solvents likely to denature the protein. The invention also relates to therapeutic compositions of an amphiphilic-BMP polymer complex according to the invention. |
申请公布号 |
US8389661(B2) |
申请公布日期 |
2013.03.05 |
申请号 |
US20080219679 |
申请日期 |
2008.07.25 |
申请人 |
SOULA GERARD;SOULA OLIVIER;SOULA REMI;ADOCIA |
发明人 |
SOULA GERARD;SOULA OLIVIER;SOULA REMI |
分类号 |
A61K31/765;A61K31/74;C08F251/00 |
主分类号 |
A61K31/765 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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