| 摘要 |
The invention relates to chimeric norovirus VP 1 proteins containing the S-domain of VP 1 of a first norovirus strain and a P-domain that contains at least a portion of the P-domain of VP l of a second norovirus strain. The invention also relates to nucleic acids that encode the chimeric VPl proteins, virus-like particles that contain a chimeric norovirus VPl protein, and to immunogenic compositions. |
