| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide TWEAK binding antibodies. <P>SOLUTION: This invention relates to an anti-TWEAK antibodies. The anti-TWEAK antibodies can be used to treat a variety of conditions and disorders, e.g., an inflammatory disorder, a neuronal disorder or other disorder described herein. When used to treat a human subject, the antibody is preferably a human, humanized or otherwise effectively human antibody. In one aspect, the disclosure features a protein that includes a first and a second immunoglobulin variable domain sequence and that binds to TWEAK, e.g., human TWEAK. The protein can bind to TWEAK, e.g., with an affinity corresponding to a K<SB POS="POST">D</SB>of less than 10<SP POS="POST">-7</SP>M, e.g., 10<SP POS="POST">-8</SP>M, 10<SP POS="POST">-9</SP>M, 10<SP POS="POST">-10</SP>M, 10<SP POS="POST">-11</SP>M or better. <P>COPYRIGHT: (C)2013,JPO&INPIT |
