| 发明名称 |
PEG-URATE OXIDASE CONJUGATE AND USE THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a safe and effective alternative for lowering elevated levels of uric acid in body fluids containing blood and urine. <P>SOLUTION: The invention relates to isolated and recombinant tetrameric mammalian uricase existing in a substantially tetrameric form and wherein 10% or less of the uricase is aggregates of non-tetrameric morphology, and the uricase is chimeric. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013039139(A) |
申请公布日期 |
2013.02.28 |
| 申请号 |
JP20120248770 |
申请日期 |
2012.11.12 |
| 申请人 |
MOUNTAIN VIEW PHARMACEUTICALS INC;DUKE UNIV |
发明人 |
WILLIAMS L DAVID;HERSHFIELD MICHAEL S;KELLY SUSAN J;SAIFER MARK G P;SHERMAN MERRY R |
| 分类号 |
C12N9/06;C12N15/09;A61K31/495;A61K38/00;A61K38/44;A61K47/34;A61K47/48;A61P13/02;A61P13/12;A61P19/06;A61P43/00;C12N11/08;C12R1/67 |
主分类号 |
C12N9/06 |
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