发明名称 |
INFECTIOUS DNA VACCINES AGAINST CHIKUNGUNYA VIRUS |
摘要 |
Described herein are i-DNA™vectors and vaccines and methods for using the same. The i-DNA™generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly chikungunya virus (CHIKV). When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.
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申请公布号 |
US2013052225(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
US201113519948 |
申请日期 |
2011.01.03 |
申请人 |
PUSHKO PETER;TRETYAKOVA IRINA;LUKASHEVICH IGOR;MEDIGEN, INC. |
发明人 |
PUSHKO PETER;TRETYAKOVA IRINA;LUKASHEVICH IGOR |
分类号 |
A61K39/12;A61P31/14;A61P37/04;C12N7/04;C12N15/85 |
主分类号 |
A61K39/12 |
代理机构 |
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