发明名称 |
ANTI-ALPHA2 INTEGRIN ANTIBODIES AND THEIR USES |
摘要 |
The invention relates to antibodies directed toα2β1 integrin and their uses, including humanized anti-alpha 2 (α2) integrin antibodies and methods of treatment with anti-α2integrin antibodies. More specifically the present invention relates to humanized anti-α2 integrin antibodies comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG1 heavy chain constant region which exhibit altered effector function. |
申请公布号 |
US2013052191(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
US201113578921 |
申请日期 |
2011.02.22 |
申请人 |
BLEIN STANISLAS;HOU SAMUEL;SKEGRO DARKO;SANOFI |
发明人 |
BLEIN STANISLAS;HOU SAMUEL;SKEGRO DARKO |
分类号 |
C07K16/18;A61K39/395;A61P1/00;A61P1/04;A61P9/10;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/06;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/63 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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