摘要 |
<p>Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyciopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.</p> |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;MCCARRON, ASHLEY, SUE;SELLS, TODD, B.;STIRLING, MATTHEW;STROUD, STEPHEN, G. |
发明人 |
MCCARRON, ASHLEY, SUE;SELLS, TODD, B.;STIRLING, MATTHEW;STROUD, STEPHEN, G. |