摘要 |
<p>The present invention provides immunosuppression compounds capable of inhibiting the programmed cell death 1 (PDl) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides an application of the compositions containing the peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of peptide moieties as a testing or diagnostic agent or a research agent for such a disease.</p> |
申请人 |
AURIGENE DISCOVERY TECHNOLOGIES LIMITED |
发明人 |
SASIKUMAR, POTTAYIL, GOVINDAN, NAIR;RAMACHANDRA, MURALIDHARA;VADLAMANI, SURESH, KUMAR;VEMULA, KOTESWARA, RAO;SATYAM, LEENA, KHARE;SUBBARAO, KRISHNAPRASAD;SHRIMALI, RAJEEV, K.;KANDEPU, SREENIVAS |