| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a stable and accurate TSLC1 detection kit which is suitable for early making a diagnosis of adult T-cell leukemia (ATL) of an HTLV-1 infected person or making a diagnosis of an ATL patient. <P>SOLUTION: In a structure of an immunochromatographic test kit, anti-TSLC1 antibodies which recognize portions different by antigen proteins are used as a labeled antibody of a labeled antibody pad and a detection antibody of a decision line. That is, a chicken IgY anti-TSLC1 monoclonal antibody (clone 3E1 Anti-SynCAM/TSLC1) is used as the labeled antibody, and a phage display human anti-TSLC1 antibody which can be accurately detected by combination with the labeled antibody is used as the detection antibody. This combination allows the accurate and stable diagnosis of ATL even when the amount of antigen TSLC1 proteins in test liquid is minute. Therefore, this invention is effective for not only the diagnosis of ATL patients but also the early diagnosis of ATL in an ATL risk group of a person infected by mother-to-child transmission of HTLV-1 who has a small amount of TSLC1 proteins. <P>COPYRIGHT: (C)2013,JPO&INPIT |
