ANTI-INFLAMMATORY DAB

摘要

The present invention provides a recombinant domain antibody (dAb) which binds to human TNF-α, the dAb comprising an immunoglobulin heavy or light chain variable domain, wherein said variable domain comprises at least one complementarity determining region (CDR) having a sequence derived from a New World primate wherein the CDR is selected from the group consisting of YAATKLQS (SEQ ID No: 1), YEASSLQS (SEQ ID No: 2), YEASKLQS (SEQ ID No: 3) and YSASNLET (SEQ ID No: 4). The recombinant domain antibody is used to detect human TNF-α in a sample and to treat a disorder characterized by human TNF-α activity.