发明名称 |
PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS |
摘要 |
<p>Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a p H-independent in vitro release profile with NMT 70 % in one hour, NMT 85 % in 4 hour, and NLT 80 % in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment- Resistant Depression (TRD) and Fragile X Syndrome.</p> |
申请公布号 |
SG187179(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
SG20130005384 |
申请日期 |
2011.08.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CHATTERJI, ASHISH;HUANG, JINGJUN;KOENNINGS, STEPHANIE;LINDENSTRUTH, KAI;SANDHU, HARPREET K.;SHAH, NAVNIT HARGOVINDAS |
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