| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a carbamazepine-cyclodextrin inclusion complex useful for the parenteral administration of carbamazepine. <P>SOLUTION: The carbamazepine-cyclodextrin inclusion complex is prepared by the admixture of a modified cyclodextrin and carbamazepine in a physiologically acceptable fluid. Modified cyclodextrins include 2-hydroxypropyl-β-cyclodextrin and sulfoalkyl cyclodextrins. More particularly, the sulfoalkyl cyclodextrins are those described and disclosed in U.S. Pat. Nos. 5,134,127 and 5,376,645. The physiologically acceptable fluid includes sterile isotonic water, lactated Ringer solution, D5W (5% dextrose in water), physiological saline, and similar fluids suitable for parenteral administration. <P>COPYRIGHT: (C)2013,JPO&INPIT |
