| 发明名称 |
COMPOSITION AND METHOD FOR DIAGNOSING AND TREATING CANCER |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions and methods for characterizing, diagnosing, and treating cancer. <P>SOLUTION: The invention provides: a soluble FZD receptor comprising an extracellular domain of a human FZD receptor that inhibits growth of tumor cells; a soluble receptor comprising a Fri domain of a human FZD receptor that binds a ligand of a human FZD receptor; and a method of treating cancer comprising a step of administering a soluble FZD receptor comprising either an extracellular domain of a human FZD receptor or a Fri domain of a human FZD receptor, in an amount effective to inhibit tumor growth. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013039127(A) |
申请公布日期 |
2013.02.28 |
| 申请号 |
JP20120183807 |
申请日期 |
2012.08.23 |
| 申请人 |
ONCOMED PHARMACEUTICALS INC |
发明人 |
GURNEY AUSTIN;LEWICKI JOHN;SATYAL SANJEEV;HOEY TIMOTHY |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P35/00;A61P43/00;C07K14/705;C07K16/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
