SYNTHESIS METHOD OF AZOXYSTROBIN AND EXCLUSIVE INTERMEDIATE IN THE SYNTHESIS THEREOF

摘要

Disclosed are a synthesis method of Azoxystrobin and an intermediate in the synthesis thereof, comprising the steps of: mixing the starting materials 3-(a-methoxyl) methylene benzofuran-2-(3H)-ketone and potassium carbonate in methylbenzene solvent, cooling to 0-10?, adding sodium methoxide, reacting for 0.4-0.6 hours; adding 4, 6-dichloropyrimide and a catalyst DABCO, reacting for 1-2 hours, filtrating and removing the inorganic salt, washing the filtrate, distilling and recovering the methylbenzene; adding a catalyst potassium hydrosulphate to the distilled residue of the previous step, under reduced pressure, heating to 132-145?for reaction; afterward, directly adding 2-hydroxy-benzonitril to synthesize the Azoxystrobin, or, after dissolving with methylbenzene, washing, and recovering the solvent, then recrystallizing and filtrating to give the intermediate (E)-2-[2-(6-chloropyrimide-4-yl-oxy) phenyl]-3-methoxyl methyl acrylate.