发明名称 |
Method for Producing Radioactively Labeled Polypeptide |
摘要 |
The present invention relates to a method for producing a polypeptide. The method includes labeling a molecular probe precursor represented by an amino acid sequence of the formula (1) using a labeling compound capable of labeling a lysine or lysine derivative: (1) Y1-Leu-Ser-Xaa12-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg- Leu-Phe-Ile-Glu-Trp-Leu-Xaa27-Asn-Gly-Y2 where Y1 represents an amino acid sequence represented by the formula (2) or the amino acid sequence represented by the formula (2) with 1 to 8 amino acids from the N-terminus being deleted, Xaa12 represents a lysine or lysine derivative, Xaa27 represents a basic amino acid having no functional group at its side chain that reacts with the labeling compound or represents methyl lysine or acetylated lysine, and Y2 represents an amino acid sequence represented by the formula (3) or the amino acid sequence represented by the formula (3) with 1 to 9 amino acids from the C-terminus being deleted: (2) His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp (3) Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser |
申请公布号 |
US2013052132(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
US201213369903 |
申请日期 |
2012.02.09 |
申请人 |
SAJI HIDEO;INAGAKI NOBUYA;KIMURA HIROYUKI;TOYODA KENTARO;HIRAO KONOMU;MATSUDA HIROKAZU;ARKRAY, INC.;KYOTO UNIVERSITY |
发明人 |
SAJI HIDEO;INAGAKI NOBUYA;KIMURA HIROYUKI;TOYODA KENTARO;HIRAO KONOMU;MATSUDA HIROKAZU |
分类号 |
C07K14/00;A61K51/08 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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