A METHOD FOR THE PREPARATION OF 2-[4-[(METHYLAMINO) CARBONYL] -1-H-PYRAZOL-1-YL] ADENOSINE MONOHYDRATE

摘要

A method for the' preparation of 2-[4-[(methylamino)carbonyl]-1-H-pyrazol-1- yl]adenosine monohydrate of formula I by reaction of 2-(4-methoxycarbonylpyrazol-1-yl) adenosine of formula III with a solution of methylamine in a non-aqueous solvent, optionally in combination with another inert solvent, to produce anhydrous 2-[4-[(methylamino)carbonyl]- 1-H-pyrazol-1-yl]adenosine, which is converted to 2-[4-[(methylamino)carbonyl]-1-H - pyrazol-1-yljadenosine monohydrate of formula I by addition of water.