发明名称 |
Novel Cationic Lipids for Oligonucleotide Delivery |
摘要 |
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is susceptible to hydrolytic instability that may translate into reduced liver residence times and reduced hepatocellular toxicity. The present invention employs acetals and ketals to provide a low pH sensitive chemical handle for degradation.
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申请公布号 |
US2013053572(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
US201113574315 |
申请日期 |
2011.01.19 |
申请人 |
COLLETTI STEVEN L.;DENG ZHENGWU JAMES;STANTON MATTHEW G.;WANG WEIMIN;HILLS IVORY |
发明人 |
COLLETTI STEVEN L.;DENG ZHENGWU JAMES;STANTON MATTHEW G.;WANG WEIMIN;HILLS IVORY |
分类号 |
C07C217/40;C07C217/52;C07D207/08;C07D207/12;C07D211/32;C07D211/44;C07D211/46 |
主分类号 |
C07C217/40 |
代理机构 |
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