COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF
摘要
<p>The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.</p>
申请公布号
EP2560489(A1)
申请公布日期
2013.02.27
申请号
EP20100850371
申请日期
2010.04.21
申请人
SIGNATURE THERAPEUTICS, INC.
发明人
JENKINS, THOMAS, E.;HUSFELD, CRAIG, O.;SEROOGY, JULIE, D.;WRAY, JONATHAN, W.