发明名称 |
FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT PIGS AND USES THEREOF |
摘要 |
Described herein is the generation of Fah+/− heterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fah−/− homozygote pigs. The Fah-deficient pigs of the disclosure can be used for a variety of research and therapeutic purposes, such as for the expansion of human hepatocytes, and as large animal models of hereditary tyrosinemia type 1, cirrhosis and hepatocellular carcinoma. |
申请公布号 |
EP2561082(A1) |
申请公布日期 |
2013.02.27 |
申请号 |
EP20110712128 |
申请日期 |
2011.03.23 |
申请人 |
OREGON HEALTH AND SCIENCE UNIVERSITY;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
GROMPE, MARKUS;NYBERG, SCOTT;LILLEGARD, JOSEPH;HICKEY, RAYMOND |
分类号 |
C12N15/85;A01K67/027;C12N15/861;G01N33/50 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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