| 摘要 |
FIELD: chemistry.SUBSTANCE: disclosed is a method of producing a radioactive, fluorine-labelled organic compound of formula, involving a step of heating a compound of formulaat temperature of 40-90°C (where Rdenotes a linear or branched alkyl with 1-10 carbon atoms or an aromatic substitute; Rdenotes a linear or a branched halogen-alkylsuphonic acid substitute with 1-10 carbon atoms, a linear or branched alkylsulphonic acid substitute with 1-10 carbon atoms, a fluorosulphonic acid substitute or an aromatic sulphonic acid substitute, and Rdenotes a protective group) while stirring in an inert organic solvent in the presence of a phase transfer catalyst,F ions and calcium ions for radioactive fluorine labelling, and concentration of the phase transfer catalyst in the inert organic solvent is not less than 70 mmol/l.EFFECT: disclosed method improves output of radioactive fluorination.5 cl, 43 ex, 5 tbl, 6 dwg |
