发明名称 |
CANCER-RELATED GLYCOPEPTIDE EPITOPES, ANTIBODIES AND METHODS OF USE |
摘要 |
Cancer-associated O-glycopeptide combination epitopes derived from the VNTR of MUC1 are disclosed. Autoantibodies present in human sera target the combination epitopes and are reduced or absent in cancer patients. The epitopes are useful as therapeutic and immunoprophylactic cancer vaccines. Monoclonal antibodies directed against the epitopes are also useful as immunotherapeutics for treatment and prevention of cancer. Diagnostic methods using the epitopes and antibodies are also disclosed. |
申请公布号 |
EP2560989(A1) |
申请公布日期 |
2013.02.27 |
申请号 |
EP20110717110 |
申请日期 |
2011.04.15 |
申请人 |
EZOSE SCIENCES, INC |
发明人 |
NISHIMURA, SHIN-ICHIRO;MATSUSHITA, TAKAHIKO;MIURA, YOSHIAKI |
分类号 |
C07K14/47;A61K38/17;A61K39/395;C07K16/30;G01N33/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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