| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to pharmacology and concerns a circulating drug carrier. The carrier contains polyethylene glycol modified phospholipid presented by general formulaor its pharmaceutically acceptable salt: wherein X represents as followsor; and n represents an integer 30 to 150 wherein Rrepresents a residue of saturated unbranched fatty acid having 17 to 22 carbon atoms, and 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoyl glycerol. Polyethylene glycol modified phospholipid is found in the amount of 30 wt % - 50 wt % of total weight of lipids in the carrier. What is also presented is a pharmaceutical composition containing the carrier described above and a drug.EFFECT: group of inventions prolongs a circulation time and respectively improves the efficacy of the drug.6 cl, 19 dwg, 5 tbl, 49 ex |
