发明名称 |
Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-oxo-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionate ester and intermediate for the process |
摘要 |
<p>A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula
wherein R 5 is a methyl group that is substituted with one or more optionally substituted phenyl groups, or an optionally substituted oxygen-containing heterocyclic group; X represents a halogen atom, can be used as a method for safely and easily preparing 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid, which is useful as an antirheumatic agent, with a high yield.</p> |
申请公布号 |
EP2562170(A1) |
申请公布日期 |
2013.02.27 |
申请号 |
EP20120007742 |
申请日期 |
2007.02.19 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
YONEZAWA, KENJI;TAKAMATSU, TAMOTSU;AOKI, NAOKATU;HASHIMOTO, TOMOHIRO;TAKEBAYASHI, MASAHIRO;SUZUKI, YOSHIAKI;OONISHI, YUJI |
分类号 |
C07D261/20;C07B61/00;C07C67/03;C07C67/303;C07C69/738;C07D311/14 |
主分类号 |
C07D261/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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