| 摘要 |
The invention relates to peptides comprising an amino acid sequence of or derived from a claudin protein for use as a pharmaceutical agent in pain therapy. The invention relates further to claudin protein as a target in pain therapy, in addition to the use of the peptides for opening the perineurium, dissociating the tight junctions of the perineurium and/or increasing paracellular permeability, preferably of ions, small molecules, pharmaceutical agents and/or high or low molecular weight compounds, through the perineurium. The peptides are therefore intended as an adjuvant for painkiller administration, such as analgesics and/or anesthetics, preferably opioids, such as morphine or DAMGO, or sodium channel blockers, such as alkaloid based toxins, for example tetrodotoxin (TTX) and/or saxitoxin (STX), thereby enhancing painkiller function. |
