| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula (I) possessing an ability to inhibit cell proliferation and IL-2 production, their pharmaceutically acceptable salts, as well as to based pharmaceutical compositions. In general formula:Rrepresents hydrogen; each of R, Rand Rindependently represents: hydrogen; halogen; -(CH)OH; (C-C)alkyl optionally substituted by one or more halogens; (C-C)alkoxy; or -(CH)NHR, wherein Rrepresents: hydrogen; -C(O)-(CH)- (6-10-member aryl) wherein aryl is optionally substituted by one or more: halogen; -SCF; (C-C)alkyl, said alkyl itself is optionally substituted by one or more halogens; or (C-C)alkoxy with said alkoxy itself being optionally substituted by one or more halogens; -C(O)-(C-C)alkyl; -C(O)-(CH)(C-C-cycloalkyl); -C(O)-(CH)-NRR, wherein each Rand Rindependently represent: hydrogen; (C-C)alkyl; 6-10-member aryl optionally substituted by one or more: halogen; (C-C)alkyl; or (C-C)alkoxy optionally substituted by one or more halogens; -C(O)-(CH)-O-(C-C)alkyl; or -C(O)-(CH)-O-(CH)-(6-10-member aryl); or Rand Rtogether can form a 6-member ring; Rrepresents hydrogen or (C-C)alkyl; Rrepresents hydrogen; and n represents 0 or 1; provided at least one of R, Rand Ris other than hydrogen.EFFECT: preparing the compounds possessing an ability to inhibit cell proliferation and IL-2 production.23 cl, 51 ex |
