| 摘要 |
<p>The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation, and self-organization processes in microjet reactors, wherein a solvent, which contains at least one target molecule, and a non-solvent are mixed as jets hitting each other in a microjet reactor at defined pressures and flow rates, wherein a very fast precipitation, a co-precipitation, or a chemical reaction occurs, whereby microparticles or nanoparticles are formed. In order to create such a method, in which the particle size of the resulting microparticles or nanoparticles can be specifically controlled, the particle size is controlled by the temperature at which the collision of the solvent with the non-solvent occurs, the flow rate of the solvent and the non-solvent, and/or the gas amount, wherein smaller particles sizes are obtained at lower temperatures, at a high flow rate of the solvent and the non-solvent, or in the complete absence of gas.</p> |
