发明名称 |
Process for preparing efavirenz polymorph |
摘要 |
The present invention relates to a process for the preparation of crystalline non-hygroscopic form H1 of efavirenz, and pharmaceutical compositions containing it. In accordance with the present invention efavirenz was dissolved in acetone at 25° C.-30° C., the solution was slowly added to water at 0° C.-5° C., the separated solid was filtered, washed with mixture of acetone and water and dried at 25° C.-35° C. under below 65% relative humidity for 18 hours to give crystalline non-hygroscopic efavirenz form H1.
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申请公布号 |
US8383811(B2) |
申请公布日期 |
2013.02.26 |
申请号 |
US20080863808 |
申请日期 |
2008.12.22 |
申请人 |
HETERO RESEARCH FOUNDATION;PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SUBASH CHANDER REDDY KESIREDDY |
发明人 |
PARTHASARADHI REDDY BANDI;RATHNAKAR REDDY KURA;RAJI REDDY RAPOLU;MURALIDHARA REDDY DASARI;SUBASH CHANDER REDDY KESIREDDY |
分类号 |
C07D265/18;A61K31/535 |
主分类号 |
C07D265/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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