Methods of preparing primary, secondary and tertiary carbinamine compounds in the presence of ammonia

摘要

The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X−, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.