| 发明名称 |
Anti-ADDL antibodies and uses thereof |
| 摘要 |
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A&bgr;-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid &bgr; 1-42.
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| 申请公布号 |
US8383113(B2) |
申请公布日期 |
2013.02.26 |
| 申请号 |
US201213368742 |
申请日期 |
2012.02.08 |
| 申请人 |
NORTHWESTERN UNIVERSITY;MERCK SHARP & DOHME CORP.;ACTON PAUL;AN ZHIQIANG;BETT ANDREW J.;BREESE ROBERT;CHANG LEI;DODSON ELIZABETH CHEN;KINNEY GENE;KLEIN WILLIAM;LAMBERT MARY P.;LIANG XIAOPING;SHUGHRUE PAUL;STROHL WILLIAM R.;VIOLA KRISTEN |
发明人 |
ACTON PAUL;AN ZHIQIANG;BETT ANDREW J.;BREESE ROBERT;CHANG LEI;DODSON ELIZABETH CHEN;KINNEY GENE;KLEIN WILLIAM;LAMBERT MARY P.;LIANG XIAOPING;SHUGHRUE PAUL;STROHL WILLIAM R.;VIOLA KRISTEN |
| 分类号 |
A61K39/395;C07K16/18;G01N33/53 |
主分类号 |
A61K39/395 |
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