| 摘要 |
Method for preparing a peptide assembly of n fragments and n-1 amino acids bearing a thiol function, represented by the formula: A1-C1-A2-C2-A3- . . . -Ci-1-Ai- . . . -Cn-1-An (I) in which A1, A2, A3, . . . Ai . . . An are peptide fragments, C1, C2, C3 . . . Ci-1 . . . Cn-1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide. |
