GENE ENCODING HUMAN GLUCOKINASE MUTANT, ENZYME ENCODED BY THE SAME, RECOMBINANT VECTORS AND HOSTS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF, METHODS FOR TREATING AND PREVENTING DISEASES

摘要

Disclosed is a human glucokinase mutant-encoding gene, wherein said gene has: A nucleotide sequence as shown in SEQ ID NO: 2; or A nucleotide sequence which is identical to the nucleotide sequence shown in SEQ ID NO: 2 except the open reading frame (ORF) ranging from position 487 to 1884 of the nucleotide sequence shown in SEQ ID NO: 2, and of which the ORF encodes the same amino acid sequence as that encoded by the ORF of the nucleotide sequence shown in SEQ ID NO: 2. Further disclosed is a recombinant vector comprising a vector and said gene, and a non-human host comprising said recombinant vector. Also disclosed is a pharmaceutical composition comprising said gene, vector and/or host, and the use of said human glucokinase mutant-encoding gene for preventing or treating diabetes mellitus.