MUC1 LIGAND TRAPS FOR USE IN TREATING CANCERS

摘要

The present invention is directed to improved compositions for the disruption of signaling through the external domain (ED) of MUCl. Ligand traps - molecules that include MUCl ED sequences and immunoglobulin Fc domains - effectively "trap" molecules that interact with the native MUCl ED. Given the involvement of MUCl in a variety of disease states, disrupting the interaction of other molecules with MUCl ED is useful in treating these disease, in particular cancer.