Fluorogenic peptide probes specific for a target molecule are provided. Exemplary florogenic peptide probes include a peptide labeled with a fluorogenic label, wherein the fluorogenic peptide probe has an unstructured three dimensional conformation in the absence of the target molecule and a structured three dimensional conformation in the presence of the target polypeptide. The structured three dimensional conformation includes an alpha-helix that forms a coiled-coil with the target molecule allowing generation of a detectable signal from the fluorogenic label in response to an exciting amount of radiation.
申请公布号
WO2013025261(A2)
申请公布日期
2013.02.21
申请号
WO2012US32583
申请日期
2012.04.06
申请人
GEORGIA TECH RESEARCH CORPORATION;ZHANG, YIYI;DUBLIN, STEVEN, N.;BAO, GANG