| 摘要 |
<p>1,241,263. Piperazine derivatives. CENTRE EUROPEEN DE RECHERCHES MAUVERNAY. 31 Oct., 1969 [14 Nov., 1968], No. 53482/69. Heading C2C. Novel piperazine derivatives of the formula in which R is a substituted or unsubstituted carbocyclic or heterocyclic radical with aromatic unsaturation and physiologically acceptable acid addition salts thereof are prepared by reacting the appropriate 2-aminobutanes with acid chlorides of the formula RCOCl. 4 - [4 - (4 - Fluorophenyl) piperazin -1 - yl] - 2- amino butane is obtained by reducing 4-[4- (4 - fluorophenyl) piperazin - 1 - yl] - 2 - butanone oxime obtained by reacting hydroxylamine hydrochloride with 4 - [4 - (4 - fluorophenyl)- piperazin-1-yl]-2-butanone, which is made by condensing (4-fluorophenyl) piperazine with trioxymethylene and acetone. Pharmaceutical compositions, suitable for oral, parenteral or rectal administration, contain the above novel piperazine derivatives or physiologically acceptable acid addition salts in association with inert carriers. The compounds possess antispasmolytic, anti-histaminic, antitussive, sedative and analgesic activities.</p> |
