| 摘要 |
1285170 Pyrido - [2,3-d] - pyrimidin - 4(3H)- ones BOEHRINGER MANNHEIM GmbH 19 April 1971 [28 March 1970] 25366/71 Heading C2C Novel compounds of the Formula I: wherein R is alkenyl or C 1-5 alkyl optionally substituted by hydroxyl or alkoxy and salts thereof with physiologically compatible acids and bases may be prepared by reacting a compound II: with a compound R-Y wherein Z is hydroxyl or a group which can be converted thereto and one of X and Y is a reactive group which will condense with a hydroxyl group or an alcoholate group to form an ether group and the other is a hydroxyl or alcoholate group, and thereafter if Z is not hydroxy, converting it to hydroxy. Pharmaceutical compounds of the Formula I show diuretic and natriuretic activity when administered orally or parenterally with the usual excipients.
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